Ruger's new SR22 pistol came out last month and looks to be a lot more reliable than some of the other polymer .22LR pistols on the market. I was looking around for the best deal I could, and KYGunCo seemed to be it. They have it for $299 w/ free shipping using personal checks. They add 3% if you use a credit card, so it is $309 shipped if you go that route. Comes with the pistol, 2 grips, (2) 10 round mags, (2) different mag floor plates, adjustable sights, and a pouch carrying case. Ordered mine a couple days ago, be here tomorrow at my FFL. They ship pretty fast and I've ordered another gun from them recently, they are a nice company to do business with.
KYGunCo Ruger SR22 [kygunco.com]
The Ruger® SR22™ pistol is the do-it-all .22 pistol for the shooter who appreciates style and demands reliability! Packed with versatile features, the SR22™ pistol is lightweight (just 17.5 ounces) and perfect for just about anything - plinking, target shooting and even small game hunting. It is easy to field-strip, fun to shoot, and will reliably accept a variety of ammunition (not just high-velocity).