~$30 for all the Advantage I Flea Medication you'll ever need

Quote from BosuxRedsux : got a quart @ walmart for $17.00. will give this a try on my 5 pound chihuahuah. maybe a half a teaspoon of this liquid?

Are you referring to the original liquid or the concentration listed in Nvuono's post?
you can't guesstimate dosage with medicine. higher concentrations mean you need to be more careful with your measurements!

Here's another way you can do it using the dosage listed in the original post:
get yourself a proper 1ml (1cc) measuring syringe with 0.1 ml increments . For a 5 lb dog, you need no more than .17ml of the Dominion (21.4% Imidacloprid), or a little less than the "2" mark (0.2 ml) on the syringe. Once you have measured out the correct amount of the Dominion product, you can dilute it in some water, then rub the whole solution on the dog's neck.


This is a very good idea, if you understand how to do it. This product is something i may look in to. For several years now, I've been buying Revolution packaged for a huge dog, and then been measuring out the proper doses for all our little animals using a similar procedure to what i described above.

This thread should be closed, it's too dangerous for the Animals.

Quote from robp : Are you referring to the original liquid or the concentration listed in Nvuono's post? you can't guesstimate dosage with medicine. higher concentrations mean you need to be more careful with your measurements! Here's another way you can do it using the dosage listed in the original post: get yourself a proper 1ml (1cc) measuring syringe with 0.1 ml increments . For a 5 lb dog, you need no more than .17ml of the Dominion (21.4% Imidacloprid), or a little less than the "2" mark (0.2 ml) on the syringe. Once you have measured out the correct amount of the Dominion product, you can dilute it in some water, then rub the whole solution on the dog's neck. The original solution. 1.47%. Got this in the garden section of walmart. Based on their measurment of a 40 lb dog of 15ml. I divide both by 8 and would get just under 2ml. I'll err on maby 1.8 ml. The chihuahuah could be over 5lbs give or take. I've tried everything sprays, flea collar and the little tube you put on both cat and dog. We even put apple vinagar in the pets bowl. Right now both have a flea collar, both are indoor pets. Got them both from a rescue and cat from a shelter. This is a very good idea, if you understand how to do it. This product is something i may look in to. For several years now, I've been buying Revolution packaged for a huge dog, and then been measuring out the proper doses for all our little animals using a similar procedure to what i described above.

I have a measuring cup and an eye dropper i was going to apply on the dogs tummy, it is bald down there.
Think this 1.47% solution be ok for cats as well?

I haven't looked through the inactive ingredients, but if you dilute down a drug solution with water you may not get the correct dose because topical solutions usually require something like ethanol or another small molecule organic solvent to carry the drugs through the skin. If that is the case then the likeliest risk is that your animal will receive a smaller dose since drug will be left unabsorbed. That also introduces the risk of ingestion if the area you applied it can be licked.

I would make sure you are using the same solvent before attempting this. Different solvent might also affect the bioactivity or bioavailability of the drug (unlikely, but possible...)

Quote from Pescador : I haven't looked through the inactive ingredients, but if you dilute down a drug solution with water you may not get the correct dose because topical solutions usually require something like ethanol or another small molecule organic solvent to carry the drugs through the skin. If that is the case then the likeliest risk is that your animal will receive a smaller dose since drug will be left unabsorbed. That also introduces the risk of ingestion if the area you applied it can be licked. I would make sure you are using the same solvent before attempting this. Different solvent might also affect the bioactivity or bioavailability of the drug (unlikely, but possible...)

I agree, hence, all these questions. Have not applied it on the dog yet.

Quote from squirty : This thread should be closed, it's too dangerous for the Animals.

Maybe move it to Deal Discussions or keep a disclaimer in the wiki, but don't close it. The fact that it may or may not be dangerous is exactly why it should be kept open; it's better to educate someone than keep them ignorant, particularly for an adult who is capable of making his or her own decisions.

This is incredibly stupid. I used to spray Imidacloprid in my greenhouse to kill citrus psyllids and other nasty buggers. I was directly instructed to wear a full body suit with a ventilator so I would not come in contact with it because it's just that dangerous.

If it's too dangerous for a human, it's even more dangerous for an animal. Don't be stupid.

Quote from jmor : This is incredibly stupid. I used to spray Imidacloprid in my greenhouse to kill citrus psyllids and other nasty buggers. I was directly instructed to wear a full body suit with a ventilator so I would not come in contact with it because it's just that dangerous. If it's too dangerous for a human, it's even more dangerous for an animal. Don't be stupid.

It's already suspended in a liquid inert concentration. Chances are the frontline product is suspended in a similar ethanol-base, which doesn't allow the active ingredient to easily separate from it. The chemical is absorbed through the skin and much of it stays on the skin and hair for quite some time depending on the environment, and how much ionizing radiation and UV the animal is exposed to.

You had to wear a 'ventilator' because you were aerosol dispersing your chemicals. Hopefully, you were actually using a respirator instead. I would also suggest eye protection. Aerosol dispersion does not allow you to easily monitor the amount of dosage you are inhaling or having contact your eyes and skin/hair.

This is only stupid if you do not know what you are doing. Asking a vet is unlikely to produce any real answers either, as few are chemist, and none have any incentive to offer any advice on this subject. However, if you do some research and measure carefully, it is as safe as any other OTC chemical. I have used permethrin, safeguard, as well as the aforementioned chemical for years.

Don't ever forget that if you use the commercially available products like frontline, et al. you are still dosing your pet with OTC chemicals. But instead of carefully measuring the product yourself to exactly fit the needs of your specific pet, you are relying on a corporations' one-size-fits-all attitude. When done correctly, it is safer and more effective.

If you are careless and ignorant, then I would suggest you do not DIY often, regardless of the project.

Quote from reindeer : It's already suspended in a liquid inert concentration. Chances are the frontline product is suspended in a similar ethanol-base, which doesn't allow the active ingredient to easily separate from it. The chemical is absorbed through the skin and much of it stays on the skin and hair for quite some time depending on the environment, and how much ionizing radiation and UV the animal is exposed to. You had to wear a 'ventilator' because you were aerosol dispersing your chemicals. Hopefully, you were actually using a respirator instead. I would also suggest eye protection. Aerosol dispersion does not allow you to easily monitor the amount of dosage you are inhaling or having contact your eyes and skin/hair. This is only stupid if you do not know what you are doing. Asking a vet is unlikely to produce any real answers either, as few are chemist, and none have any incentive to offer any advice on this subject. However, if you do some research and measure carefully, it is as safe as any other OTC chemical. I have used permethrin, safeguard, as well as the aforementioned chemical for years. Don't ever forget that if you use the commercially available products like frontline, et al. you are still dosing your pet with OTC chemicals. But instead of carefully measuring the product yourself to exactly fit the needs of your specific pet, you are relying on a corporations' one-size-fits-all attitude. When done correctly, it is safer and more effective. If you are careless and ignorant, then I would suggest you do not DIY often, regardless of the project.

Yes, a respirator. Thank you for correcting me. I just remember wearing full body protection and that it was very dangerous. Especially at the 21.4% OP is recommending.

I have been using the otc version of this for a year now, my dogs are fine. I am glad I found this post, I am going to pick up a bottle of this. I think if you are carefull, this is great. If you are not, well stay away.

Thanks op.