Do you happen to have those tweak settings (or a website with a guide)?
Sure! Off the top of my head, a few settings tweaks are:
In Protection Center, Application Control:
For unknown applications: Move to the following group automatically: Untrusted
Cuts down on constant background heuristic analysis
In Scan, General Settings, Background Scan:
Uncheck "Perform regular rootkit scan."
Largely unnecessary and eats up CPU.
In Advanced Settings, Gaming Profile Settings: :
Check "Use Gaming Profile" and check whatever profile options you'd like.
I disabled IM Anti-virus and Mail Anti-Virus since they're both unnecessary given my setup. You can choose to turn off specific warnings pertaining to disabled components.
Also have set the program to exclude lots of trusted applications from monitoring, scans, etc. Like Steam, certain games, etc.