Angel Eyes' active ingredient is a type of antibiotics called Tylosin, which is generally used to treat animal diarrhea. It does work to reduce tear stains. But after using it for two weeks, I decided that the unknown risks of long term use is far too great for cosmetic purposes. I learned to live with the panda look of my malteses. But if do wan to use it, you can buy Tylosin directly at much cheaper per dose price. You can Google to find out the right dose for the weight of your dogs.