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120-Count Sundown Naturals 300 mcg Melatonin Tablets EXPIRED

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Amazon has 120-Count Sundown Naturals 300 mcg Melatonin Tablets on sale for $1.54 when you 'clip' the $1 off coupon and click on "Skip immediate delivery and just add subscription" or "Subscribe Now" to checkout via Subscribe & Save. Shipping is free. Thanks Dorylus

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Clip $1 coupon and checkout with Subscribe & Save - $1.27 with 5+ subscriptions

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A Harvard study found that 300mcg is about the equivalent of what our bodies naturally produce and is thus more effective. You may notice less residual grogginess and side effects with the lower dosage. 3-5mg is way more melatonin than we should be taking in a night yet that's the easiest to find. (Melatonin is dirt cheap so it doesn't cost much more to sell 3mg capsules.)
20 Helpful?
Bioavailability is a very poor predictor of efficacy with melatonin due to complex interactions leading to a rare pharmacokinetic exception where peak serum levels correspond more with clincial efficacy than the standard area under the curve. All studies are based on peak serum plasma levels, and the most quoted "physiological" serum levels correspond to a much lower dose than most OTC doses. In fact, 5mg corresponds to a peak serum concentration ~25x that of peak "physiological" nocturnal values.

Very common mistake, even amongst doctors. I've corrected several primary care physicians on this point just the past year alone. For what it's worth, I had great success with this same dose when I was having problems falling asleep the couple months I was studying for my boards.
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Hey, I know some of those words!
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HIDDEN ngsm13 03-11-2018 at 11:47 AM
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Thanks OP, just started a subscription at full price and was able to cancel.
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#5
Quote from ngsm13
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What good is 300mcg?

IIRC, normal dosage is 3-5mg. I take 5mg nightly... If I travel usually 15mg to help flip my jet lag.
A Harvard study found that 300mcg is about the equivalent of what our bodies naturally produce and is thus more effective. You may notice less residual grogginess and side effects with the lower dosage. 3-5mg is way more melatonin than we should be taking in a night yet that's the easiest to find. (Melatonin is dirt cheap so it doesn't cost much more to sell 3mg capsules.)
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Quote from MICHAELSD
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A Harvard study found that 300mcg is about the equivalent of what our bodies naturally produce and is thus more effective. You may notice less residual grogginess and side effects with the lower dosage. 3-5mg is way more melatonin than we should be taking in a night yet that's the easiest to find. (Melatonin is dirt cheap so it doesn't cost much more to sell 3mg capsules.)
Here's a link to a MIT one.
http://news.mit.edu/2005/melatonin

I personally use this exact product, and it works great for nights my sleep schedule deviates.
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#7
300mcg may be closer to what our bodies produce, but how much of that is actually bioavailable? You never get 100% of what you put in when going through the digestive system.

That being said, 3mg makes me groggy. I find 1mg is a decent dosage. Everyone is different, though. At least with this, you can take 1, 2, or 3 if needed.
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#8
Quote from flapjack
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300mcg may be closer to what our bodies produce, but how much of that is actually bioavailable? You never get 100% of what you put in when going through the digestive system.

That being said, 3mg makes me groggy. I find 1mg is a decent dosage. Everyone is different, though. At least with this, you can take 1, 2, or 3 if needed.
Looks like bioavailability is about 15% as tested with 2-4mg tablets: https://www.ncbi.nlm.nih.gov/pubmed/10883420
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#9
To me, 300mcg gives you dosage flexibility. You also shouldn't rely on melatonin to correct your poor sleep habits.
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Add-on now
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#11
add-on, deal is dead


.
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#12
Worked for me, $1.27! Add on is available but so was S&S. Thanks!
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#13
I was using a 3mg tablet, but after reading the MIT article, I started breaking up the tablet and taking a small amount, approx 300-500mcg and it has been very effective and easier to get up in the morning. Now I can use this. At this price I won't feel bad about wasting the other tablets.

Thanks got one
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Quote from Megiddo
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Here's a link to a MIT one.
http://news.mit.edu/2005/melatonin

I personally use this exact product, and it works great for nights my sleep schedule deviates.
thanks for the link
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#15
Causes nightmares
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