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#76
Quote from wushufanatic
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Indeed there may be a potential interference mainly from caffeine blunting the effects of creatine. In addition to a greater potential for GI upset, creatine increases calcium clearance in skeletal muscle which reduces muscle relaxation time whereas caffeine does the opposite by allowing for a greater release of calcium and reducing calcium clearance thereby increasing relaxation time. This is important as for the proteins in skeletal muscle to cycle, relaxation needs to occur. An interesting area that clearly needs more research but the current recommendation is that if the effects of creatine are prioritized, chronic dosing of caffeine should be limited such that it is only used during high priority training sessions and/or competition.

Trexler, E. T., & Smith-Ryan, A. E. (2015). Creatine and caffeine: Considerations for concurrent supplementation. International journal of sport nutrition and exercise metabolism, 25(6), 607-623.
A bit late with this but thank you for the link! Very helpful information.
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