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240-Count Puritans Pride 3mg Melatonin Supplement EXPIRED

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Amazon has 240-Count Puritans Pride 3mg Melatonin Supplement on sale for $2.44 - 5% Subscribe & Save = $2.32. Shipping is free while Subscribe & Save is available. Thanks busybugsy

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Puritans Pride Melatonin 3 mg Tablets, 240 Count https://www.amazon.com/dp/B004R65...5DbQ3KVEZJ
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"Melatonin is available in some countries, including the United States, as an over-the-counter preparation. We suggest the use of low, physiologic doses (0.1 to 0.5 mg) for insomnia or jet lag (Grade 2B). High-dose preparations raise plasma melatonin concentrations to a supraphysiologic level and may desensitize brain melatonin receptors, which could alter normal day/night melatonin rhythms."

Source: UpToDate
https://www.uptodate.com/contents...-melatonin
10 Helpful?
If I take enough of this will it make me black?
10 Helpful?
Heads up that many people need as little as 300 mcg (1/10 of this dosage) to get significant effects from melatonin and that taking too large a dose can actually be counterproductive.

For me, the sweet spot seems to be 600mcg

Sources:

http://doi.org/10.17925/USN.2014.10.02.117

A very small dose (0.3 mg) of melatonin is usually sufficient to restore nighttime plasma melatonin levels to those characteristic of young people, and to accelerate the resumption of sleep after premature awakenings. The much larger doses that are marketed can produce side effects that are not observed when the melatonin in the plasma derives solely from its secretion by the pineal.

https://academic.oup.com/jcem/art...27/2849013

The physiologic melatonin dose (0.3 mg) restored sleep efficiency (P < 0.0001), acting principally in the midthird of the night; it also elevated plasma melatonin levels (P < 0.0008) to normal. The pharmacologic dose (3.0 mg), like the lowest dose (0.1 mg), also improved sleep; however, it induced hypothermia and caused plasma melatonin to remain elevated into the daylight hours. Although control subjects, like insomniacs, had low melatonin levels, their sleep was unaffected by any melatonin dose.
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#3
Good time to buy some melatonin if you are still awake 😂
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#4
Good price regardless
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.....
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Last edited by phiota December 3, 2019 at 08:13 AM.
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#6
Heads up that many people need as little as 300 mcg (1/10 of this dosage) to get significant effects from melatonin and that taking too large a dose can actually be counterproductive.

For me, the sweet spot seems to be 600mcg

Sources:

http://doi.org/10.17925/USN.2014.10.02.117

A very small dose (0.3 mg) of melatonin is usually sufficient to restore nighttime plasma melatonin levels to those characteristic of young people, and to accelerate the resumption of sleep after premature awakenings. The much larger doses that are marketed can produce side effects that are not observed when the melatonin in the plasma derives solely from its secretion by the pineal.


https://academic.oup.com/jcem/art...27/2849013

The physiologic melatonin dose (0.3 mg) restored sleep efficiency (P < 0.0001), acting principally in the midthird of the night; it also elevated plasma melatonin levels (P < 0.0008) to normal. The pharmacologic dose (3.0 mg), like the lowest dose (0.1 mg), also improved sleep; however, it induced hypothermia and caused plasma melatonin to remain elevated into the daylight hours. Although control subjects, like insomniacs, had low melatonin levels, their sleep was unaffected by any melatonin dose.
Reply Helpful Comment? 9 4
Last edited by jonaswashe December 3, 2019 at 11:10 AM.
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#7
Quote from jonaswashe
:
Heads up that many people need as little as 300 mcg (1/10 of this dosage) to get significant effects from melatonin and that taking too large a dose can actually be counterproductive.

For me, the sweet spot seems to be 600mcg.
Source?
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#8
I take 5 minimum for it to work for me thanks op
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#9
If I take enough of this will it make me black?
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#10
Stocking up, melatonin always helps me sleep!
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#11
already dead?
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#12
It can't find the page when I click subscribe and save and I can't add it to my cart.
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#13
Looks like its not available anymore
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12-03-2019 at 08:42 AM
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#15
Back up to 6.81, Expired?
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