32-Count Pedigree Dentastix Dog Dental Treats (Original w/ Real Chicken for Large Dogs)

It's food, every single food product for every single organism is YMMV. I would say the review score indicates a buyer may not need to be worried about this product an appreciable amount more than any general food product.

Just out of curiosity since I bought these last time they were on sale for my dog, I looked at a 1 star review of a seller complaining about the awful ingredients. They site a totally reputable site (whatever that site is who knows) as the source for their complaints.

Wheat - Tufts mentions it as an off hand comment somewhat recommending it. https://vetnutrition.tufts.edu/20...strations/
Cellulose - Eh, I mean yeah "it could be sawdust" might be right but people love to draw comparisons between something that seems like it shouldn't be consumed and damning it. This reviewer does it throughout the review.
STPP - good for teeth https://pubmed.ncbi.nlm.nih.gov/18309857/
Salt - Is high up on the list. Ingredients are listed by weight. Salt crystals are much larger than vitamins and generally consumed in larger quantities. I mean compare what magnitude of sodium intake vs vitamin intake for a person. Dogs obviously should get less sodium but I think it demonstrates my point that's probably where it should belong if there is salt in the product. https://www.akc.org/expert-advice...-for-dogs/
Potassium Sorbate - https://efsa.onlinelibrary.wiley.....2012.2735
Smoke flavor - not sure how broad this could be but artificial flavoring has never been objectively bad health wise, people just love to stomp on it for not being natural. People do that all the time for food stuffs. Either way the most common way to get smoky flavor for people is liquid smoke, thought there was artificial but can't find an example. Liquid smoke is natural, just grabs the "smoky" flavor that you get from the wood and condenses it into liquid https://efsa.onlinelibrary.wiley.....2012.2729
- Iron Oxide - https://efsa.onlinelibrary.wiley.....2016.4482

Learned a couple things looking this stuff up. But to sum it up, most likely nothing sketchy with the product, just the normal ymmv for food stuffs.

edit: forgot to mention but the thing that does make me kind of wary is the calorie amount for how I feed my dog. For the 40 lb dog threshold for this dentastix, you'd probably be looking at ~860 kcal (https://petnutritionalliance.org/...?type=dogs). I've seen 10% max kcal should come from treats as the recommendation so this (78 kcal) would almost hit that 10% max immediately. I like to give my dog more treats throughout the day (and for training) so I have to be mindful of how many treats I gave her that day to not exceed. Of course do your own research, kcal suggestions are always based on dog activity, size, prone to obesity/if you've seen anything to worry that the calories will be problematic, veterinarian suggestions, etc.

and do note these aren't meant to replace brushing.