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Optimum Nutrition Opti-Men Daily Multivitamin Supplement, 90 Count $15.72
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Amazon has Optimum Nutrition Opti-Men Daily Multivitamin Supplement, 90 Count for $15.72 (Reg $31.99) when you clip coupon on product page
https://www.amazon.com/dp/B0015R3A7M?
https://www.amazon.com/dp/B0015R3A7M?
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Amazon has Optimum Nutrition Opti-Men Daily Multivitamin Supplement, 90 Count for $15.72 (Reg $31.99) when you clip coupon on product page
https://www.amazon.com/dp/B0015R3A7M?
https://www.amazon.com/dp/B0015R3A7M?
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What the primary-prevention evidence shows (general adults)
- No mortality benefit. Pooled across 9 RCTs (n≈51,550), multivitamins were not associated with lower all-cause mortality (OR 0.94, 95% CI 0.87–1.01). The largest trial, COSMOS (n=21,442), found no difference (HR 0.93, 95% CI 0.81–1.08). [1-2]
- No cardiovascular benefit. No association with cardiovascular mortality (OR 0.94, 95% CI 0.83–1.06). [2]
- A small, uncertain cancer signal. A modest reduction in cancer incidence was seen (OR 0.93, 95% CI 0.87–0.99), but absolute risk differences were tiny (−0.2% to −1.2%), the effect on cancer mortality was not significant, and the incidence and mortality findings were discordant — limiting confidence. [1]
- Bottom line from USPSTF (2022): Evidence is insufficient to recommend for or against multivitamins for preventing cardiovascular disease or cancer (I statement). The Task Force explicitly recommends against beta-carotene (harm — increased lung cancer/CV mortality) and vitamin E (no benefit). [2]
The exercise angle specifically- Exercise does stress metabolic pathways requiring B vitamins, iron, and antioxidants, and can increase micronutrient losses (sweat, urine), so requirements may be modestly higher in athletes. [3][5-6]
- However, micronutrient intake rises in parallel with the higher energy intake that active people consume, and studies of micronutrient status do not show deficiency in trained individuals eating a normal mixed diet. Moderate activity is "not likely to be very much above" general-population requirements. [7]
- Both American College of Sports Medicine position stands are explicit: vitamin/mineral supplements do not improve performance in people consuming nutritionally adequate diets, and routine supplementation is only warranted to correct a documented deficiency. [3-4]
- Notably, high-dose antioxidant supplementation (vitamins C and E) may actually blunt training adaptations, so it is not advisable for someone training to gain fitness. [4]
Who does benefit (i.e., the real indications)Supplementation is justified when intake is inadequate or requirements are elevated — restrictive/low-energy diets, elimination of food groups, pregnancy/lactation (folic acid), aging, malabsorption, chronic disease, or a lab-confirmed deficiency (commonly iron, vitamin D, calcium). [4][6][8] For these situations, a targeted single-nutrient correction based on testing is generally preferred over a broad multivitamin. [4][6]
Practical takeaway
For a healthy adult with a solid diet who trains recreationally and has no deficiency, a daily men's multivitamin is low-risk but of unproven benefit — a "food-first" approach is what the evidence and sports-nutrition guidelines support. [4][6] It is reasonable as cheap insurance against dietary gaps, but it should not be expected to enhance performance, recovery, or long-term health outcomes. Products should also be checked for beta-carotene and high-dose vitamin E/A content, given the identified harms.
1.
Vitamin and Mineral Supplements for the Primary Prevention of Cardiovascular Disease and Cancer.
[IMG]https://www.openevidence.com/_next/image?url=https%3A%2F%2Fwww.google.com%2Fs2%2Ffavicons%3Fdomain%3Dhttps%3A%2F%2Fjamanetwork.com%2F%26sz%3D32&w=48&q=75[/IMG]The Journal of the American Medical Association. 2022.O'Connor EA, Evans CV, Ivlev I, et al.SR
2.
Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: US Preventive Services Task Force Recommendation Statement.
[IMG]https://www.openevidence.com/_next/image?url=https%3A%2F%2Fwww.google.com%2Fs2%2Ffavicons%3Fdomain%3Dhttps%3A%2F%2Fjamanetwork.com%2F%26sz%3D32&w=48&q=75[/IMG]The Journal of the American Medical Association. 2022. US Preventive Services Task Force, Mangione CM, Barry MJ, et al.Guideline
3.
American College of Sports Medicine Position Stand. Nutrition and Athletic Performance.
Medicine and Science in Sports and Exercise. 2009. Rodriguez NR, Di Marco NM, Langley S.Guideline
4.
American College of Sports Medicine Joint Position Statement. Nutrition and Athletic Performance.
Medicine and Science in Sports and Exercise. 2016. Thomas DT, Erdman KA, Burke LM.Guideline
5.
Effect of Physical Activity on Thiamine, Riboflavin, and Vitamin B-6 Requirements.
The American Journal of Clinical Nutrition. 2000.Manore MM.Review
6.
Micronutrient Requirement in Sports and Exercise.
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. 2025. Carlsohn A.RecentReview
7.
Micronutrients: Interaction Between Physical Activity, Intakes and Requirements.
Public Health Nutrition. 1999. Fogelholm M.Review
8.
Micronutrients — Assessment, Requirements, Deficiencies, and Interventions.
The New England Journal of Medicine. 2025. Allen LH
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