This collaborative space allows users to contribute additional information, tips, and insights to enhance the original deal post. Feel free to share your knowledge and help fellow shoppers make informed decisions.
Deal History includes data from multiple reputable stores, such as Best Buy, Target, and Walmart. The lowest price among stores for a given day is selected as the "Sale Price".
Sale Price does not include sale prices at Amazon unless a deal was posted by a community member.
I think it's awesome when you all give the expiration dates. For me, who has issues sleeping, I'll have no trouble using them up by the end of May. I imagine most normal people probably don't go through them quite as quick as I do
I think it's awesome when you all give the expiration dates. For me, who has issues sleeping, I'll have no trouble using them up by the end of May. I imagine most normal people probably don't go through them quite as quick as I do
Oh you are preachin' to the choir to me about that
It is a joke with every single one of my friends/coworkers that if anyone is gonna used expired things, it's gonna be me. The joke is that "Well we aren't ever gonna go to her house to eat" and on and on
However I do know that some people really do pay attention to expiration dates so information like that will be important to them.
From Up to date online. World wide medical reference
OVER-THE-COUNTER SLEEP AIDSOver-the-counter (OTC) sleep aids are fully regulated by the US Food and Drug Administration (FDA), including composition, doses, indications, manufacture, and marketing. One of two approved sleep aids (diphenhydramine, doxylamine) are in these products, and they are marketed solely for sleep or combined with analgesics (acetaminophen, ibuprofen) as "PM" formulations.
Benefits of these sleep aids are the easy OTC access and relative safety; however, caution is necessary when recommending these medications, especially with long-term use or with older adults or when used concomitantly with medications having sedating or anticholinergic properties [9]. Tolerance may develop with extended use. Some individuals take very large amounts attempting to attain sedating effects.
Due to possible anticholinergic effects, they should be used very cautiously in older adults because of confusion and delirium risk [89].
●Mechanism of action – Intended sedation is due to postsynaptic histamine H1 receptor antagonism. Postsynaptic muscarinic antagonism may cause undesired anticholinergic effects [22,60].
●Dosing – Most preparations contain the following recommended doses. It is best to use lowest effective dose.
•Diphenhydramine – 25 to 50 mg at bedtime
•Doxylamine – 25 mg 30 minutes before bedtime
●Metabolism and interactions – The approximate elimination half-life of diphenhydramine is 9 to 10 hours and slightly longer for doxylamine (10 to 12 hours). Half-lives may be shorter in children and longer in older adults.
●Side effects – The most common side effects are sedation, dizziness, disturbed coordination, epigastric distress, and thickening of bronchial secretions. Warnings/contraindications include narrow-angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy, and bladder-neck obstruction.
●Efficacy – Diphenhydramine is associated with a mean reduction in sleep onset of approximately eight minutes compared with placebo and a 12-minute improvement in total sleep time [1]. Contemporary data are not available for doxylamine [90,91].
From Up to date online. World wide medical reference
OVER-THE-COUNTER SLEEP AIDSOver-the-counter (OTC) sleep aids are fully regulated by the US Food and Drug Administration (FDA), including composition, doses, indications, manufacture, and marketing. One of two approved sleep aids (diphenhydramine, doxylamine) are in these products, and they are marketed solely for sleep or combined with analgesics (acetaminophen, ibuprofen) as "PM" formulations.
Benefits of these sleep aids are the easy OTC access and relative safety; however, caution is necessary when recommending these medications, especially with long-term use or with older adults or when used concomitantly with medications having sedating or anticholinergic properties [9]. Tolerance may develop with extended use. Some individuals take very large amounts attempting to attain sedating effects.
Due to possible anticholinergic effects, they should be used very cautiously in older adults because of confusion and delirium risk [89].
●Mechanism of action – Intended sedation is due to postsynaptic histamine H1 receptor antagonism. Postsynaptic muscarinic antagonism may cause undesired anticholinergic effects [22,60].
●Dosing – Most preparations contain the following recommended doses. It is best to use lowest effective dose.
•Diphenhydramine – 25 to 50 mg at bedtime
•Doxylamine – 25 mg 30 minutes before bedtime
●Metabolism and interactions – The approximate elimination half-life of diphenhydramine is 9 to 10 hours and slightly longer for doxylamine (10 to 12 hours). Half-lives may be shorter in children and longer in older adults.
●Side effects – The most common side effects are sedation, dizziness, disturbed coordination, epigastric distress, and thickening of bronchial secretions. Warnings/contraindications include narrow-angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy, and bladder-neck obstruction.
●Efficacy – Diphenhydramine is associated with a mean reduction in sleep onset of approximately eight minutes compared with placebo and a 12-minute improvement in total sleep time [1]. Contemporary data are not available for doxylamine [90,91].
anticholinergic also causes constipation (for me). Use melatonin instead.
anticholinergic also causes constipation (for me). Use melatonin instead.
Caution: I have read that Melatonin has its own set of issues (no experience for me), just be careful if you take anything at all.
I am on the fence. The deal for Costco is great! More than a lifetime supply for me. My spouse has an Rx for sleepy pills. I only need occasional help. So I am going to pass since it isn't really a big problem. Side effects can suck for anything. Canceled my AMZ order, but I am also a little worried about Melatonin for now.
Paralyzed, figuratively, so I must not need these enough.
Caution: I have read that Melatonin has its own set of issues (no experience for me), just be careful if you take anything at all.
I am on the fence. The deal for Costco is great! More than a lifetime supply for me. My spouse has an Rx for sleepy pills. I only need occasional help. So I am going to pass since it isn't really a big problem. Side effects can suck for anything. Canceled my AMZ order, but I am also a little worried about Melatonin for now.
Paralyzed, figuratively, so I must not need these enough.
for sure. as little as 1mg of melatonin and for sure i get lucid dreams and depending on quickly i take it, nightmares....pretty scary ones too. this is natrol.
Like
Helpful
Funny
Not helpful
Sign up for a Slickdeals account to remove this ad.
This is the same ingredient as Benadryl for $0.10 per soft gel.
You can get tons of different packages of diphenhydramine as low as $0.027 per dose at Walmart.
The only real difference is that these are softgels. I've never noticed a difference between them, tablets and capsules but maybe there is? To me, this is not a deal at all.
Leave a Comment
18 Comments
Sign up for a Slickdeals account to remove this ad.
Ty!
It still shows in stock for me and lets me add it to my cart.
Are you seeing the seller as Amazon Warehouse?
Ty!
Oh you are preachin' to the choir to me about that
It is a joke with every single one of my friends/coworkers that if anyone is gonna used expired things, it's gonna be me. The joke is that "Well we aren't ever gonna go to her house to eat" and on and on
However I do know that some people really do pay attention to expiration dates so information like that will be important to them.
https://www.costco.com/kirkland-s...28084.html
If we break this down Tofuvic style, the cost is .013 per 25 MG vs .099 per 25MG if you need to have it in gel form.
They will both do the same thing, one might act slightly quicker then the other...
https://www.costco.com/kirkland-s...28084.html
If we break this down Tofuvic style, the cost is .013 per 25 MG vs .099 per 25MG if you need to have it in gel form.
They will both do the same thing, one might act slightly quicker then the other...
From now on, we're gonna call you the Tofuvic of sleeping pills
(ty)
Sign up for a Slickdeals account to remove this ad.
OVER-THE-COUNTER SLEEP AIDSOver-the-counter (OTC) sleep aids are fully regulated by the US Food and Drug Administration (FDA), including composition, doses, indications, manufacture, and marketing. One of two approved sleep aids (diphenhydramine, doxylamine) are in these products, and they are marketed solely for sleep or combined with analgesics (acetaminophen, ibuprofen) as "PM" formulations.
Benefits of these sleep aids are the easy OTC access and relative safety; however, caution is necessary when recommending these medications, especially with long-term use or with older adults or when used concomitantly with medications having sedating or anticholinergic properties [9]. Tolerance may develop with extended use. Some individuals take very large amounts attempting to attain sedating effects.
Due to possible anticholinergic effects, they should be used very cautiously in older adults because of confusion and delirium risk [89].
●Mechanism of action – Intended sedation is due to postsynaptic histamine H1 receptor antagonism. Postsynaptic muscarinic antagonism may cause undesired anticholinergic effects [22,60].
●Dosing – Most preparations contain the following recommended doses. It is best to use lowest effective dose.
•Diphenhydramine – 25 to 50 mg at bedtime
•Doxylamine – 25 mg 30 minutes before bedtime
●Metabolism and interactions – The approximate elimination half-life of diphenhydramine is 9 to 10 hours and slightly longer for doxylamine (10 to 12 hours). Half-lives may be shorter in children and longer in older adults.
●Side effects – The most common side effects are sedation, dizziness, disturbed coordination, epigastric distress, and thickening of bronchial secretions. Warnings/contraindications include narrow-angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy, and bladder-neck obstruction.
●Efficacy – Diphenhydramine is associated with a mean reduction in sleep onset of approximately eight minutes compared with placebo and a 12-minute improvement in total sleep time [1]. Contemporary data are not available for doxylamine [90,91].
OVER-THE-COUNTER SLEEP AIDSOver-the-counter (OTC) sleep aids are fully regulated by the US Food and Drug Administration (FDA), including composition, doses, indications, manufacture, and marketing. One of two approved sleep aids (diphenhydramine, doxylamine) are in these products, and they are marketed solely for sleep or combined with analgesics (acetaminophen, ibuprofen) as "PM" formulations.
Benefits of these sleep aids are the easy OTC access and relative safety; however, caution is necessary when recommending these medications, especially with long-term use or with older adults or when used concomitantly with medications having sedating or anticholinergic properties [9]. Tolerance may develop with extended use. Some individuals take very large amounts attempting to attain sedating effects.
Due to possible anticholinergic effects, they should be used very cautiously in older adults because of confusion and delirium risk [89].
●Mechanism of action – Intended sedation is due to postsynaptic histamine H1 receptor antagonism. Postsynaptic muscarinic antagonism may cause undesired anticholinergic effects [22,60].
●Dosing – Most preparations contain the following recommended doses. It is best to use lowest effective dose.
•Diphenhydramine – 25 to 50 mg at bedtime
•Doxylamine – 25 mg 30 minutes before bedtime
●Metabolism and interactions – The approximate elimination half-life of diphenhydramine is 9 to 10 hours and slightly longer for doxylamine (10 to 12 hours). Half-lives may be shorter in children and longer in older adults.
●Side effects – The most common side effects are sedation, dizziness, disturbed coordination, epigastric distress, and thickening of bronchial secretions. Warnings/contraindications include narrow-angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy, and bladder-neck obstruction.
●Efficacy – Diphenhydramine is associated with a mean reduction in sleep onset of approximately eight minutes compared with placebo and a 12-minute improvement in total sleep time [1]. Contemporary data are not available for doxylamine [90,91].
anticholinergic also causes constipation (for me). Use melatonin instead.
I am on the fence. The deal for Costco is great! More than a lifetime supply for me. My spouse has an Rx for sleepy pills. I only need occasional help. So I am going to pass since it isn't really a big problem. Side effects can suck for anything. Canceled my AMZ order, but I am also a little worried about Melatonin for now.
Paralyzed, figuratively, so I must not need these enough.
I am on the fence. The deal for Costco is great! More than a lifetime supply for me. My spouse has an Rx for sleepy pills. I only need occasional help. So I am going to pass since it isn't really a big problem. Side effects can suck for anything. Canceled my AMZ order, but I am also a little worried about Melatonin for now.
Paralyzed, figuratively, so I must not need these enough.
Sign up for a Slickdeals account to remove this ad.
You can get tons of different packages of diphenhydramine as low as $0.027 per dose at Walmart.
The only real difference is that these are softgels. I've never noticed a difference between them, tablets and capsules but maybe there is? To me, this is not a deal at all.
Leave a Comment