40-Oz Blue Diamond Almonds (Lightly Salted or Smokehouse) Expired

I actually thought about not responding to your post because your fearmongering would make it easier for me to buy more almonds. However, I felt morally obligated to post that your assumption of only 50% from first-pass metabolism is actually not at all plausible.

80% of cyanide is metabolized outright by the liver into thiosulfate. Thiosulfate is pretty unremarkable except in extreme circumstances (ie: getting a direct IV drip at a high dose over an extended duration of time). An additional 1-10% of cyanide is metabolized to ACTA (some references actually report 15-20% metabolism, but I'm giving you the benefit of the doubt). As you can imagine, this actually leaves very little cyanide left which is why you don't hear many stories of subclinical (much less clinical) cyanide poisoning via almond consumption.

Furthermore, you cited the toxic blood concentration, but your math seems to treat the human body as a 1-compartment distribution model. However, most substances (including cyanide) do not follow a 1-compartment model. Stuff doesn't just stay in the blood after absorption. Instead, stuff will further distribute into cells, tissues, and other compartments in the body.

In our almond situation, the small amount of cyanide that your body fails to metabolize will largely distribute into cells and tissues. In fact, 70-96% of un-metabolized cyanide will distribute into cells and tissues, and that amount is not measured in a blood draw. Importantly, this distribution effect is accounted for when they set toxic blood concentrations for substances, and it's partly why the toxic blood concentration for cyanide is so low (because they know that cyanide distributes largely into your cells and tissues).

Here is the source I used for cyanide distribution and metabolism - https://www.ncbi.nlm.nih.gov/pmc/...MC3977587/
It's also a number that's cited multiple times. Here's another article - https://www.ncbi.nlm.nih.gov/pmc/...MC3793392/

Using your numbers for toxicity and human blood volume and taking the lowest scientifically known values for cyanide metabolism and subsequent distribution, 1 oz of almonds would come out to 0.041 mg in the entire body. This leads to a blood concentration of 0.00008316 mg/dL. If I were to eat 2.2 pounds (1 kg) of almonds in a day, this would still come out to 0.000182952 mg/dL. In fact, if I were to light it up and eat 100 kilos of sweet almonds in a rage-infused almond eating binge, I would still be an order of magnitude away from even starting to approach 30% of the number that you quoted as the early concentration of lethality (nevermind the normal concentration for lethality). And this is all with the most conservative numbers for cyanide metabolism and distribution.

Lastly, in case anyone is wondering, the enzymes used for metabolizing cyanide are not in short supply. Long term sweet almond exposure won't slowly whittle down a small temporary supply of enzymes. You will be fine.

However, if you feel that your cyanide metabolism may be specially impaired, you should certainly feel free to not buy these. I would appreciate having an extra bag for myself to eat.

Almonds are should not be consumed by your dog. Not worth the risk. Please don't have children.