Update: This popular deal is still available
Amazon has
400-Count 20mg Amazon Basic Care Maximum Strength Acid Reducer Famotidine Tablets for $12.89 - 5% off when you check out via Subscribe & Save =
$12.25.
Shipping is free w/ Prime or on orders $25+.
Thanks to Slickdeals Deal Hunter
Navy-Wife for posting this deal.
Note: You may cancel Subscribe & Save any time after your order ships.
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What does this do?
Amazon is notorious for dropping prices on perishables once they are close to being expired.
It's happened to me multiple times on a bunch of SD alerts I took advantage of and purchased.
The only risk of long term PPI therapy shown in the updated medical literature at this time is intestinal infection. Concerns about kidney injury, dementia, malnutrition, osteoporosis, and other concerns previously expressed 5-10 years ago are unfounded. Thus, PPIs are quite safe to use long term and significantly more effective than Pepcid/famotidine at reducing stomach acid secretion.
Having said that, PPIs do get overprescibed and should only be used for an appropriate indication at the lowest effective dose.
She may want to consider dietary elimination diets such as 2, 4, and 6-food elimination diets to keep her eosinophilic esophagitis under control if she wants to potentially avoid being on medications long term
If these therapies fail, usually the next step is topical steroids (Flovent inhaler without a spacer, or topical budesonide from either a compounded pharmacy or DIY using Pulmicort respules). These steroids have high rates of first pass metabolism (ie, the liver inactivates them before they hit the rest of the body, so they don't carry the same risks of systemic steroids like prednisone).
There are also emerging therapies such as dupilumab, a monoclonal antibody that has also been used in eczema and asthma. There will hopefully be more biologics on the market in the coming years.
Note that all of the therapies above work on reducing the inflammation (ie, eosinophils) in the esophagus. To decrease the pre-existing scar tissue/fibrosis, some patients may also need endoscopies with esophageal dilation.
H2 blockers such as famotidine suffer from tachyphylaxis -- ie, they become less effective when used on a regular basis. If you are needing to take an H2 blocker on a regular basis, you probably should be on a PPI (eg omeprazole), which doesn't have this same problem.
H2 blockers typically aren't used in the treatment of eosinophilic esophagitis.
+1. First line therapy would be PPI or an elimination diet. The most common elimination diet is the six food elimination diet (SFED = milk, wheat, soy, tree nuts, eggs, fish/shellfish), although any elimination diet will be difficult in a teenager. Commonly after taking PPI or going on an SFED, an upper endoscopy with esophageal biopsies is repeated to evaluate for histologic response (ie, to see if the eosinophil count has decreased/normalized). It can be a bit cumbersome as to do an SFED properly involves multiple endoscopies with food reintroduction between the scopes to see which foods can be reintroduced vs need to stay eliminated.
If these therapies fail, usually the next step is topical steroids (Flovent inhaler without a spacer, or topical budesonide from either a compounded pharmacy or DIY using Pulmicort respules). These steroids have high rates of first pass metabolism (ie, the liver inactivates them before they hit the rest of the body, so they don't carry the same risks of systemic steroids like prednisone).
There are also emerging therapies such as dupilumab, a monoclonal antibody that has also been used in eczema and asthma. There will hopefully be more biologics on the market in the coming years.
Note that all of the therapies above work on reducing the inflammation (ie, eosinophils) in the esophagus. To decrease the pre-existing scar tissue/fibrosis, some patients may also need endoscopies with esophageal dilation.
My GI MD also said to elevate bed since I have GERD overnight (wake up in pain now but clears up as soon as I'm up. Haven't tried it yet.
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https://www.med.stanfor
My GI MD also said to elevate bed since I have GERD overnight (wake up in pain now but clears up as soon as I'm up. Haven't tried it yet.
Cheaper than 250 at Sam's ($10).
I have mild reflux. Probably based on my diet before bed.
Anyways, if I use famotidine a couple hours before bed, I don't experience (or experience less reflux symptoms) during sleep and sleep through the night. If I miss a dose, I can definitely wake up if the pain gets bad enough or cough/vomit up acid.
That said, PPI may be better, but I got off that when my EGD came back normal and there were a lot of health concerns with long term PPI use. When I stopped the PPI, rebound GERD was really bad. Worse than normal baseline. It took like 2 weeks to get over that.
Now you can just buy it yourself for the same purpose.
PPIs don't fix anything, they simply reduce the acid to "hide" the problem, but it causes its own set of problems. Side effects of prolonged use are common, so avoid it if possible.
The only thing that has worked for me is to avoid carbs and fiber (per the fast tract diet) and some spices...problem is that a lot of carbs are very tasty
Yes they do. Alongside a otc daily allergy med, helped alot.
Amazon is notorious for dropping prices on perishables once they are close to being expired.
It's happened to me multiple times on a bunch of SD alerts I took advantage of and purchased.
Exp: 01/2024
#1/day = 400 days, so these will be fine.
In truth, even expired, they'll retain 80% potency. Likewise, unlike ranitidine, expired famotidine has not been associated with the toxic chemical - N-Nitrosodimethylamine (NDMA).
https://jamanetwork.com/journals/...le/2775725
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It's called GERD